Abstracts And Publications

Onboard, tethered IL-12 boosts potency of the Tmod NOT gate and preserves selectivity

Zhang J, Imboden S, Lee D, et al.

Journal of Immunotherapy of Cancer: May 2025.

The next stage of immune cell design: selective targeting of multi-antigen profiles

Kamb A, Egen J.

Frontiers in Immunology: March 2025.

Multi-targeted, NOT gated CAR-T cells as a strategy to protect normal lineages for blood cancer therapy

DiAndreth B, Nesterenko P, Winters A, et al.

Frontiers in Immunology: March 2025.

High-throughput screen to identify and optimize NOT gate receptors for cell therapy

Martire S, Wang X, McElvain M, et al.

Cytometry: The Journal of the International Society for Analytical Cytology: August 2024.

Detecting HLA loss of heterozygosity within a standard diagnostic sequencing workflow for prognostic and therapeutic opportunities

Lozac’hmeur A, Danek T, Yang Q, et al.

npj Precision Oncology: August 2024.

NOT Gated T Cells That Selectively Target EGFR And Other Widely Expressed Tumor Antigens

Oh J, Kirsh C, Hsin JP, et al.

iScience: May 2024.

Geometric Parameters That Affect The Behavior Of Logic-Gated CAR T Cells

Partin AC, Bruno R, Shafaattalab S, et al.

Frontiers in Immunology: January 2024.

Genomic Immune Evasion: Diagnostic and Therapeutic Opportunities in Head and Neck Squamous Cell Carcinomas

Kirtane K, St. John M, Fuentes-Bayne H, et al.

Journal of Clinical Medicine: December 2022.

HLA-A∗02-gated Safety Switch for Cancer Therapy Has Exquisite Specificity for Its Allelic Target Antigen

Mock JY, Winters A, Riley TP, et al.

Molecular Therapy: October 2022.

The Tmod Cellular Logic Gate As a Solution for Tumor-selective Immunotherapy

DiAndreth B, Hamburger A, Xu H, et al.

Clinical Immunology: August 2022.

The End of an Era of Cancer Drug Discovery: Life Without New Drug Targets

Mardiros A, Kamb A.

Immuno-oncology Insights: April 2022.

Robust In Vitro Pharmacology of Tmod, A Synthetic Dual-Signal Integrator for Cancer Cell Therapy

Manry D, Bolanos K, DiAndreth B, et al.

Frontiers in Immunology: March 2022.

A Carcinoembryonic Antigen-specific Cell Therapy Selectively Targets Tumor Cells with HLA Loss of Heterozygosity in Vitro and In Vivo

Sandberg M, Wang X, Martin A, et al.

Science Translational Medicine: March 2022.

Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity

Tokatlian T, Asuelime G, Naradikian M, et al.

Cancer Research Communications: January 2022.

A Rational Approach to Assess Off-Target Reactivity of a Dual-Signal Integrator for T Cell Therapy

Wang X, Wong LM, McElvain M, et al.

Toxicology and Applied Pharmacology: January 2022.

Mesothelin-Specific CAR-T Cell Therapy that Incorporates an HLA-Gated Safety Mechanism Selectively Kills Tumor Cells

Tokatlian T, Asuelime G, Mock JY, et al.

Journal of ImmunoTherapy for Cancer: January 2022.

Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Wang X, Sandberg M, Martin A, et al.

Journal of Immunotherapy: October 2021.

Extensive Functional Comparisons Between Chimeric Antigen Receptors and T-cell Receptors Highlight Fundamental Similarities

Wang X, Martin A, Negri K, et al.

Molecular Immunology: October 2021.

Design of TCR Structural Variants That Retain or Invert the Normal Activation Signal

Mock JY, Oh J, Yi J, et al.

ImmunoHorizons: May 1, 2021.

Re-examination of MAGE-A3 as a T-cell Therapeutic Target

Martin A, Wang X, Sandberg M, et al.

Journal of Immunotherapy: April 2021.

**HLA-A*02:01-directed Chimeric Antigen Receptor/Forkhead Box P3-engineered CD4+ T cells Adopt a Regulatory Phenotype and Suppress Established Graft-versus-host Disease**

Martin A, Daris M, Johnston J, et al.

Cytotherapy: February 2021.

Engineered T-cells Directed at Tumors with Defined Allelic Loss

Hamburger A, DiAndreth B, Cui J, et al.

Molecular Immunology: December 2020.

A Multivariate, Quantitative Assay that Disentangles Key Kinetic Parameters of Primary Human T Cell Function In Vitro

Huang GL, Nampe DP, Yi J, et al.

PLoS ONE: November 2020.

Structure-function Relationships of Chimeric Antigen Receptors in Acute T-cell Responses to Antigen

Xu H, Hamburger A, Mock JY, et al.

Molecular Immunology: October 2020.

Cancer T-cell Therapy: Building the Foundation for a Cure

Kamb A, Go W, et al.

F1000 Research: November 2020.

Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs

Oh J, Warshaviak D, Mkrtichyan M, et al.

Scientific Report: November 2019.

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