Our Science

Abstracts and Publications

Select A2 Bio Scientific Publications

HLA-A∗02-gated Safety Switch for Cancer Therapy Has Exquisite Specificity for Its Allelic Target Antigen

Mock JY, Winters A, Riley TP, et al. Molecular Therapy: October 2022.

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The Tmod Cellular Logic Gate As a Solution for Tumor-selective Immunotherapy

DiAndreth B, Hamburger A, Xu H, et al. Clinical Immunology: August 2022.

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The End of an Era of Cancer Drug Discovery: Life Without New Drug Targets

Mardiros A, Kamb A. Immuno-oncology Insights: April 2022.

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Robust In Vitro Pharmacology of Tmod, A Synthetic Dual-Signal Integrator for Cancer Cell Therapy

Manry D, Bolanos K, DiAndreth B, et al. Frontiers in Immunology: March 2022.

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A Carcinoembryonic Antigen-specific Cell Therapy Selectively Targets Tumor Cells with HLA Loss of Heterozygosity in Vitro and In Vivo

Sandberg M, Wang X, Martin A, et al. Science Translational Medicine: March 2022.

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Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity

Tokatlian T, Asuelime G, Naradikian M, et al. Cancer Research Communications: January 2022.

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A Rational Approach to Assess Off-Target Reactivity of a Dual-Signal Integrator for T Cell Therapy

Wang X, Wong LM, McElvain M, et al. Toxicology and Applied Pharmacology: January 2022.

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Mesothelin-Specific CAR-T Cell Therapy that Incorporates an HLA-Gated Safety Mechanism Selectively Kills Tumor Cells

Tokatlian T, Asuelime G, Mock JY, et al. Journal of ImmunoTherapy for Cancer: January 2022.

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Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Wang X, Sandberg M, Martin A, et al. Journal of Immunotherapy: October 2021.

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Extensive Functional Comparisons Between Chimeric Antigen Receptors and T-cell Receptors Highlight Fundamental Similarities

Wang X, Martin A, Negri K, et al. Molecular Immunology: October 2021.

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Design of TCR Structural Variants That Retain or Invert the Normal Activation Signal

Mock JY, Oh J, Yi J, et al. ImmunoHorizons: May 1, 2021.

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Re-examination of MAGE-A3 as a T-cell Therapeutic Target

Martin A, Wang X, Sandberg M, et al. Journal of Immunotherapy: April 2021.

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HLA-A*02:01-directed Chimeric Antigen Receptor/Forkhead Box P3-engineered CD4+ T cells Adopt a Regulatory Phenotype and Suppress Established Graft-versus-host Disease

Martin A, Daris M, Johnston J, et al. Cytotherapy: February 2021.

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Engineered T-cells Directed at Tumors with Defined Allelic Loss

Hamburger A, DiAndreth B, Cui J, et al. Molecular Immunology: December 2020.

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A Multivariate, Quantitative Assay that Disentangles Key Kinetic Parameters of Primary Human T Cell Function In Vitro

Huang GL, Nampe DP, Yi J, et al. PLoS ONE: November 2020.

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Structure-function Relationships of Chimeric Antigen Receptors in Acute T-cell Responses to Antigen

Xu H, Hamburger A, Mock JY, et al. Molecular Immunology: October 2020.

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Cancer T-cell Therapy: Building the Foundation for a Cure

Kamb A, Go W. F1000 Research: November 2020.

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Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs

Oh J, Warshaviak D, Mkrtichyan M, et al. Scientific Report: November 2019.

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BASECAMP-1: Leveraging HLA-A Loss of Heterozygosity in Solid Tumors by NGS to Identify Patients with Relapsed Solid Tumors for Future CEA and MSLN Logic-gated Tmod CAR T-cell Therapy.

Simeone DM, Morelli MP, Hecht JR, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2022.

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An NGS Assay to Identify HLA-A Loss of Heterozygosity for Future CEA and MSLN Logic-gated CAR-T Solid Tumor Protocols Designed for Reduced On-target, Off-tumor Toxicity

Kopetz S, Morelli MP, Molina J, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2022.

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A2B530, An Autologous CEA-directed Tmod T-cell therapy with An Inhibitory Receptor Gated by HLA-A*02 to Target Colorectal, Pancreatic, and Lung Cancer

Hecht, JR Sandberg ML, Wang X, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2022.

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A2B694, An Autologous Logic-gated Cell Therapy Targeting Mesothelin

Molina J, Tokatlian T, Wang J, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2022.

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A Powerful, Precise Targeting System Controlled by Tumor Deletions Transforms CEA and MSLN CAR-T Cells Into Tumor-Selective Agents

Hamburger A, Xu H, Ando Y, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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BASECAMP-1: An Observational Study to Identify Relapsed Solid Tumor Patients with Human Leukocyte Antigen (HLA) Loss of Heterozygosity (LOH) and Leukapheresis for Future CAR T Cell Therapy

Molina J, Go W, Kopetz S, et al. Poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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A Computational Approach to Predict Off-target Peptide Selectivity of pMHC Targeting Therapeutics

Warshaviak D, Nampe D, Wang X, et al. Poster presentation at The Essential Protein Engineering & Cell Therapy Summit Virtual. August 2020.

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Breanna DiAndreth, PhD, on Improving Selective Targeting of Tumor Cells

DiAndreth A. Interview conducted at Onco Cell Therapy Summit (OCTS) USA 2022. June 2022.

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The Future of Logic-gated Cell Therapy

Go W. Interview conducted at the 4th International Workshop on CAR-T (iwCAR-T 2022). April 2022.

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Julian Molina genetherapylive

Treating Solid Tumors With Personalized Immunotherapy: Julian Molina, MD, PhD

Molina J. Interview conducted at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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Julian Molina genetherapylive

Improving Specificity of T-Cell Therapies in Solid Tumors: Julian Molina, MD, PhD

Molina J. Interview conducted at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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Tmod™ T cell Therapy Platform Overview

Kamb, A. Interviews conducted at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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BASECAMP-1: An Observational Study to Identify Relapsed Solid Tumor Patients with Human Leukocyte Antigen (HLA) Loss of Heterozygosity (LOH) and Leukapheresis for Future CAR T Cell Therapy

Molina J. Oral poster presentation at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC). November 2021.

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Managing Clinical Safety and Toxicity for Improved Patient Outcomes

Go W. Oral presentation at CAR-TCR Summit 2021. August 2021.

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Optimizing Efficiency in Trial Sponsor and Clinician Relationships

Geiger B, Matthews A, Melvin P, et al. Panel discussion at CAR-TCR Summit 2021. August 2021.

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Next-generation Logic-gated Cell Therapy

Go W. Oral presentation at the International Workshop on CAR-T 2021. April 2021.

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Engineered T Cells Directed at Tumors with Defined Allelic Loss

Hamburger A, DiAndreth B, Cui J, et al. Oral presentation at 3rd Cell Therapies and Immunotherapy Conference. October 2020.

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